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    Home » Supplements

    Best Probiotics for Histamine Intolerance

    Last Updated: Oct 31, 2025 by Natalie Perry · This post may contain affiliate links · 2 Comments

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    Looking for the best probiotics for histamine intolerance? You're not alone. Choosing the right probiotic strains can feel confusing, especially when you're trying to balance gut health while managing histamine-related symptoms. This guide breaks down which probiotics can help support your gut microbiome and which ones to avoid on a low-histamine diet.

    A hand holding a single probiotic capsule. this …

    ⚡ Quick Look: Best Probiotics for Histamine Intolerance

    • Top Probiotic Strains: Low-histamine strains such as Lactobacillus plantarum, Bifidobacterium longum, Lactobacillus rhamnosus, Bifidobacterium bifidum, Saccharomyces boulardii, and Bacillus coagulans help calm histamine reactions and support gut balance.
    • Strains to Avoid: Some probiotics, including Lactobacillus casei, Streptococcus thermophilus, Lactobacillus bulgaricus, and Lactobacillus helveticus, may increase histamine levels in sensitive individuals.
    • Why It Matters: Histamine intolerance often begins in the gut. Supporting your microbiome with the right probiotics can reduce symptoms like headaches, bloating, and skin reactions.
    • Choosing a Supplement: Look for clearly labeled strain types and high-quality formulas made for histamine-sensitive individuals. Pair probiotics with a clean, whole-food diet for best results.
    • Tips for Success: Start with one strain at a time, track your body's response, and be consistent. Healing takes time, but the right probiotic support can make a significant difference.

    Summarize and Save This Content On

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    Jump to:
    • ⚡ Quick Look: Best Probiotics for Histamine Intolerance
    • Why You'll Love This Post
    • Identifying Low-Histamine Probiotic Strains
    • Probiotic Strains to Avoid for Histamine Intolerance
    • Understanding Histamine Intolerance
    • The Impact of Probiotics
    • Choosing the Right Probiotic Supplements
    • Tips for Incorporating Probiotics
    • Final Thoughts
    • Comments

    Why You'll Love This Post

    Your gut bacteria play a powerful role in digestion, immune function, and even mental health. Probiotics are beneficial microorganisms that help maintain balance in your gut flora - but not all probiotics work the same way.

    Here's the important part:
    Some probiotic strains can actually produce histamine in your digestive tract. If you struggle with histamine sensitivity, histamine intolerance, or conditions like Mast Cell Activation Syndrome (MCAS), you may need to avoid certain strains and foods that can trigger symptoms.

    The right probiotic supplement can make a big difference in digestion, energy, and overall wellness - helping you move from discomfort to a calmer, healthier gut.

    Supporting your gut with nourishing foods and fermented drinks, like my Colon Cleanse Juice or Raw Kefir, is one of the easiest ways to strengthen your microbiome naturally.

    When I focused on healing my gut, I saw dramatic improvements in my histamine intolerance symptoms. I had less itchiness, fewer migraines, and reduced bloating. Working closely with my doctor, I found natural solutions that finally helped me feel like myself again.

    If you'd like to go further, check out Anti-Inflammatory Foods and Eating Unprocessed Food Diet. Both guides are packed with practical tips to restore balance and support your body through food.

    Please note: this information is for educational purposes only and should not replace professional medical care. Always consult a qualified healthcare provider before changing your supplement routine, especially if you have a medical condition.

    Identifying Low-Histamine Probiotic Strains

    Managing histamine intolerance involves selecting the right probiotic strains. These probiotics can make a significant difference in your gut health.

    Microscopic view of bacteria labeled "Low Histamine Probiotic Strains," suggesting beneficial strains for those with histamine intolerance.

    1. Lactobacillus Plantarum: This probiotic strain is one of the best in the low-histamine probiotic category. Lactobacillus plantarum can aid in histamine breakdown. This is often what is missing in the gut of those with histamine intolerance. This strain supports a balanced gut microbiome while helping to manage histamine levels.

    2. Bifidobacterium Longum: Bifidobacterium longum is another beneficial probiotic for those with histamine issues. It promotes a healthy digestive system and has a positive impact on overall gut health. This strain is known to have a low histamine-producing potential.

    3. Lactobacillus Rhamnosus: Lactobacillus rhamnosus is renowned for its health benefits. It can help stabilize the gut microbiome without significantly increasing histamine production, making it suitable for individuals on a low-histamine diet.

    4. Bifidobacterium bifidum: Bifidobacterium bifidum is known for its ability to support the balance of white blood cells and mast cells in the gut. It may also be helpful with irritable bowel syndrome (IBS). This balance is crucial for preventing allergic symptoms and histamine-related issues. 

    5. Saccharomyces boulardii: While technically a yeast-based probiotic, Saccharomyces boulardii is often used to complement other probiotics. It doesn't produce histamine and can be a useful addition to your probiotic regimen.

    6. Bacillus Coagulans: Bacillus coagulans is a spore-forming probiotic that survives the harsh conditions of the digestive tract. It supports a balanced gut microbiome and is less likely to trigger histamine production.

    These specific strains are considered the best choice for individuals dealing with histamine intolerance. Probiotic supplements containing these strains can be found in various forms, such as capsules or powders.

    When choosing a supplement, ensure it specifies the strains present and opt for products designed for a low-histamine diet.

    Probiotic Strains to Avoid for Histamine Intolerance

    While specific probiotic strains can be incredibly beneficial for gut health, some may pose risks for individuals with histamine intolerance due to their potential to increase histamine levels in the digestive tract.

    A magnifying glass highlights the word "AVOID" over a blurred list, indicating certain probiotic strains to steer clear of for histamine intolerance.

    1. Lactobacillus Casei: This probiotic strain has been shown to increase the production of histamine during the fermentation process. For individuals with histamine intolerance, this could lead to the release of histamine in the gut, potentially triggering symptoms like digestive discomfort and skin reactions. 

    However, more studies are needed to confirm this. To stay on the safe side, it may be best to avoid it while rebalancing your gut and histamine reactions.

    2. Lactobacillus Bulgaricus

    3. Bifidobacterium Infantis: While generally considered a beneficial probiotic, Bifidobacterium infantis may affect histamine levels differently in different individuals. Some may experience an increase in histamine production, leading to digestive symptoms.

    4. Streptococcus Thermophilus: Streptococcus thermophilus is commonly used in yogurt production. It can play a role in histamine production during the fermentation process.

    5. Lactobacillus Helveticus: This strain can impact histamine receptors and amino acid metabolism in the gut. Its effects may vary among individuals, making it challenging to predict its impact on histamine levels.

    6. Lactobacillus Delbrueckii: This is another strain used in dairy fermentation, but it may not be suitable for those with histamine issues.

    7. Lactobacillus Saerimneri

    Image of a bottle of capsules spilled onto a marble surface with a wooden spoon; the text reads "Best Probiotics For Histamine Intolerance - MindfullyHealthyLiving.com

    Understanding Histamine Intolerance

    Before looking into the best probiotics for histamine intolerance, it is important to understand what histamine intolerance is. Many people experience histamine intolerance, which can manifest in various ways. Here's what it means and how it relates to gut health.

    Histamine Intolerance Explained: Histamine is a natural compound present in our bodies. It plays an important role in immune response and regulating stomach acid.

    However, some individuals experience histamine intolerance due to an imbalance in histamine levels.

    This can occur when there's an insufficient amount of diamine oxidase (DAO) in the small intestine. DAO is an enzyme responsible for breaking down histamine. Another way histamine intolerance occurs is due to conditions like small intestinal bacterial overgrowth (SIBO). SIBO can also stimulate the production of excess histamine.

    A 3D rendering of a cell with particles representing histamine around it, with text "Understanding Histamine Intolerance," likely explaining the condition's biological basis.

    Common Symptoms: Histamine intolerance symptoms can vary from person to person. They often include:

     *Digestive issues like diarrhea, abdominal pain, and bloating

    *Skin rashes, headaches, and seasonal allergies resembling hay fever

    *Elevated histamine levels can worsen inflammatory responses in conditions like ulcerative colitis.

    *Episodic migraine patients may find histamine to be a trigger as well.

    The Importance of a Low Histamine Diet: Managing histamine intolerance often begins with dietary changes. A low histamine diet involves avoiding histamine-rich foods and those that trigger histamine release. This can alleviate symptoms and reduce the overall histamine load on the body.

    The Gut-Histamine Connection: The gut plays a pivotal role in histamine metabolism.

    A healthy small intestine with a balanced microbiome helps maintain proper histamine degradation.

    Conditions like leaky gut can make histamine issues worse by allowing histamine to pass through the intestinal barrier and into the bloodstream. This may end up triggering allergic reactions, among other symptoms.

    The Impact of Probiotics

    Probiotics play a pivotal role in maintaining a healthy gut microbiome. For individuals dealing with histamine intolerance, understanding the benefits and potential risks associated with probiotics is crucial. Many people look for the best probiotics for histamine intolerance because of the major impact this choice can have on those who struggle with histamine issues.

    3D illustration of blue bacteria with a gradient background and text that says "The Impact of Probiotics," possibly discussing the positive effects of probiotics on health.

    Maintaining a Healthy Gut Microbiome: Probiotics are beneficial bacteria that, when consumed, can populate the gastrointestinal tract. They help establish a balanced gut microbiota, fostering an environment where friendly bacteria thrive. This balance is essential for digestive health, immune function, and maintaining gut motility.

    Benefits for Those with Histamine Intolerance: Probiotics offer several potential benefits for individuals with histamine intolerance. Certain strains, such as Lactobacillus plantarum, have been studied for their role in histamine metabolism and the breakdown of histamine in the gut. They can help mitigate histamine symptoms and improve overall gut health.

    Histamine Release and Probiotics: However, it's vital to note that not all probiotics are created equal. Some strains have been associated with triggering histamine release in the gut, potentially exacerbating histamine intolerance symptoms. 

    To explore a more comprehensive list of probiotic-rich foods and their benefits for gut health, check out our article on the "Best Probiotic Foods for Gut Health."

    Choosing the Right Probiotic Supplements

    Selecting the ideal probiotic supplement tailored to your specific needs can significantly impact your journey toward better gut health and managing histamine intolerance. When choosing the right probiotics for histamine intolerance, it is important to consider the quality of the product as well as the strain. Here's a guide to help you make informed choices:

    A person is selecting a bottle of probiotic supplements from a pharmacy shelf; text overlay states "Choosing the Right Probiotic Supplement."

    Read Product Labels: When browsing for probiotic supplements, always start by examining the product labels. Look for information on the strains of probiotic bacteria included in the supplement. For individuals with histamine intolerance, prioritize supplements that mention strains known for low histamine production.

    Specific Strains Matter: Not all probiotic strains have the same effects on the body. Research shows that certain strains, such as Lactobacillus plantarum and Bifidobacterium longum, are generally well-tolerated by those with histamine issues. These strains can promote gut health without increasing histamine levels.

    Reputable Brands: Trustworthy brands that specialize in probiotics can be a good place to start your search. They often provide detailed information about the strains and colony-forming units (CFUs) in their products. Look for brands that emphasize quality and transparency in their manufacturing processes.

    Low Histamine Options: Some reputable brands offer probiotic supplements explicitly designed for individuals with histamine intolerance or sensitivities. These supplements are formulated to minimize histamine production while supporting digestive health. Brands that offer low histamine probiotic options include Seeking Health, Ora Organic, and Bioma. 

    Consider Co-Factors: It's also worth considering supplements that include co-factors such as vitamin B 6, B 12, Copper, and Iron, which can support the activity of DAO enzymes responsible for histamine breakdown.

    Consult a Professional: If you have specific dietary restrictions or challenging conditions related to histamine intolerance, consider consulting a healthcare professional or nutritionist. They can provide personalized recommendations tailored to your unique needs.

    Don't forget to subscribe to our weekly newsletter to get the latest wellness info and healthy recipes directly in your inbox! You can also follow us on social media!

    Tips for Incorporating Probiotics

    A woman is about to consume a pill, with a glass of water in her other hand; text overlay gives "Tips for Incorporating Probiotics."

    1. Choose the Right Supplement: As mentioned earlier, opt for probiotic supplements with strains suitable for histamine intolerance. Read product labels carefully to ensure they meet your specific needs. Check out our guide on reading labels: ingredients to avoid.

    2. Consistency is Key: Probiotics work best when taken consistently. To help you remember, set a daily schedule or incorporate them into an existing routine, like breakfast or dinner.

    3. Start Slowly: If you're new to probiotics or have a sensitive gut, start with a lower dose and gradually increase it. This allows your body to adjust comfortably.

    4. Refrigerate When Necessary: Some probiotics require refrigeration to maintain their potency. Store them as recommended to preserve their efficacy.

    5. Time it Right: While probiotics can be taken with or without food, some people find it helpful to take them just before or after a meal. Experiment to see what works best for you.

    6. Diversify Your Diet: Probiotic-rich foods can complement your probiotic regimen. Incorporate yogurt, kefir, kimchi, sauerkraut, and other fermented foods into your meals. These foods provide a natural source of beneficial bacteria.

    *However, if you have histamine intolerance, it may be best to avoid fermented foods at first and use probiotic supplements with low histamine probiotic strains. Once you've got a handle on things, you can take time to slowly reintroduce probiotic foods.

    7. Prebiotic Foods: Include prebiotic-rich foods like garlic, onions, leeks, and asparagus in your diet. Prebiotics serve as nourishment for probiotics, helping them thrive in your gut.

    Check out our guide to Colon Broom vs Metamucil vs Psyllium Husk for fiber supplement recommendations.

    8. Stay Hydrated: Proper hydration is essential for a healthy gut. Drink plenty of water to support the growth and activity of probiotics in your digestive system. Learn more about the benefits of spring water here!

    9. Limit Sugar and Processed Foods: High-sugar and processed foods can disrupt the balance of good bacteria in your gut. Minimize your intake to create a favorable environment for probiotics to flourish. Start here with our guide to a diet that excludes processed food.

    10. Monitor Your Body: Pay attention to how your body responds to probiotics and dietary changes. If you experience any adverse effects or unusual symptoms, consult a healthcare professional for guidance.

    Final Thoughts

    Managing histamine intolerance is a journey that involves careful choices and dedicated self-care. Probiotics can be valuable for you once you select the right strains that align with your body and needs.

    Don't miss our article on Coffee and Histamine Intolerance. I've researched low-histamine coffee brands and share advice for coffee lovers navigating histamine issues. (I've been there!)

    Have you found a probiotic strain that works for you? What is your favorite? We would love to hear your thoughts and experiences. Feel free to share in the comments below!

    Have a healthy day,

    Natalie

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      Recipe Rating




    1. Alison says

      December 21, 2023 at 7:48 am

      This post is great. I've been trying to research more about histamine issues and it often seems very daunting. I love that I was able to grab my probiotic and look for each specific strain needed.

      Reply
      • Natalie Perry says

        December 22, 2023 at 10:39 pm

        I have definitely been there, too! Let me know if you have any questions!

        Reply
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    Hello there! My name is Natalie. My passion is creating and sharing healthy recipes, tips, and affirmations for a healthy mind and body. I am a wife, mom, certified holistic nutrition specialist, hypnotherapist, reiki master, and healthy food blogger! I enjoy learning, creating, and sharing healthy recipes that the whole family will love.

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